Enhanced cord blood stem cell transplants safe in long-term studies
(Medical Xpress) -- An innovative experimental treatment for boosting the effectiveness of stem-cell transplants with umbilical cord blood has a favorable safety profile in long-term animal studies,...
View ArticleTeam demonstrates breakthrough method of stem cell expansion
(Medical Xpress) -- Researchers in the Department of Pathology at Stony Brook University School of Medicine have discovered a laboratory method to expand adult hematopoietic stem cells (HSCs) using the...
View ArticleStem cells central to pathogenesis of mature lymphoid tumors
New research suggests that blood stem cells can be involved in the generation of leukemia, even when the leukemia is caused by the abnormal proliferation of mature cells. The study, published by Cell...
View ArticleResearchers successfully perform first injection of cultured red blood cells...
For the first time, researchers have successfully injected cultured red blood cells (cRBCs) created from human hematopoietic stem cells (HSCs) into a human donor, according to study results published...
View ArticleScientists successfully expand bone marrow-derived stem cells in culture
All stem cells -- regardless of their source -- share the remarkable capability to replenish themselves by undergoing self-renewal. Yet, so far, efforts to grow and expand scarce hematopoietic (or...
View ArticleModeling cancer using ecological principles
The invasion of a new species into an established ecosystem can be directly compared to the steps involved in cancer metastasis. New research published in BioMed Central's open access journal...
View Article3-D long-term bone marrow culture to analyze stromal cell biological function
Stromal cells, as distinct from hematopoietic cells, are an essential component of the bone marrow microenvironment and are necessary for the long-term maintenance of hematopoietic stem cells (HSCs) in...
View ArticlePhase I trial begins using gene therapy and bone marrow stem cells in the...
University Hospitals (UH) Case Medical Center, Case Western Reserve University School of Medicine and Lentigen Corporation announced today the initiation of a novel Phase I clinical trial of LG631 gene...
View ArticleAging stem cells may explain higher prevalence of leukemia, infections among...
Human stem cells aren't immune to the aging process, according to scientists at the Stanford University School of Medicine. The researchers studied hematopoietic stem cells, which create the cells that...
View ArticleStudy unlocks origins of blood stem cells
A research team led by Nancy Speck, PhD, professor of Cell and Developmental Biology at the Perelman School of Medicine at the University of Pennsylvania, has discovered a molecular marker for the...
View ArticleUse of stem cells, conditioning induces immune tolerance
(HealthDay) -- A novel approach using a bioengineered mobilized cellular product enriched with hematopoietic stem cells (HSCs) and tolerogenic graft facilitating cells (FCs) in combination with...
View ArticleAged hematopoietic stem cells rejuvenated to be functionally younger
Researchers have rejuvenated aged hematopoietic stem cells to be functionally younger, offering intriguing clues into how medicine might one day fend off some of the ailments of old age.
View ArticleFDA approves DUCORD product for stem cell transplants
Duke University School of Medicine has received approval from the Food and Drug Administration to market DUCORD, a stem cell product derived from umbilical cord blood, for use in transplants between...
View ArticleNew stem cell research, transplant strategies show promise to improve...
Studies of stem cell biology and transplant approaches presented today at the 54th Annual Meeting of the American Society of Hematology (ASH) illustrate how the use of advanced modeling techniques is...
View ArticleEnzyme accelerates malignant stem cell cloning in chronic myeloid leukemia
An international team, headed by researchers at the University of California, San Diego School of Medicine, has identified a key enzyme in the reprogramming process that promotes malignant stem cell...
View ArticleOne of the key circuits in regulating genes involved in producing blood stem...
Researchers from the group on stem cells and cancer at IMIM (Hospital del Mar Medical Research Institute) have deciphered one of the gene regulation circuits which would make it possible to generate...
View ArticleEpidermal growth factor aids stem cell regeneration after radiation damage
Epidermal growth factor has been found to speed the recovery of blood-making stem cells after exposure to radiation, according to Duke Medicine researchers. The finding could open new options for...
View ArticleStem cell survival strategy key to blood and immune system health
Stem cells of the aging bone marrow recycle their own molecules to survive and keep replenishing the blood and immune systems as the body ages, researchers at UC San Francisco (UCSF) have discovered.
View ArticleFat cells prolong survival of human stem cells grown in vitro
One of the main obstacles that stands in the way of using human hematopoietic stem cells (hHSCs) to treat a variety of diseases is the difficulty growing them in culture—they quickly die or...
View ArticleThe surprising ability of blood stem cells to respond to emergencies
A research team of Inserm, CNRS and MDC lead by Michael Sieweke of the Centre d'Immunologie de Marseille Luminy (CNRS, INSERM, Aix Marseille Université) and Max Delbrück Centre for Molecular Medicine,...
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